PPAR gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice
نویسندگان
چکیده
1 Univ Lille Nord de France, F-59000, Lille, France 2 Inserm, U1011, F-59000, Lille, France 3 UDSL, F-59000, Lille, France 4 Institut Pasteur de Lille, F-59019, Lille, France 5 Department of Molecular Genetics, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, The Netherlands 6 Department of Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
منابع مشابه
Peroxisome Proliferator–Activated Receptor- Gene Level Differently Affects Lipid Metabolism and Inflammation in Apolipoprotein E2 Knock-In Mice
Objective—Peroxisome proliferator–activated receptor(PPAR ) is a ligand-activated transcription factor that controls lipid metabolism and inflammation. PPAR is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia. Previous studies assessing the influence of PPAR agonists on atherosclerosis in mice yielded conflicting results, and the implication of PPAR therein has n...
متن کاملPeroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice.
OBJECTIVE Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor that controls lipid metabolism and inflammation. PPARα is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia. Previous studies assessing the influence of PPARα agonists on atherosclerosis in mice yielded conflicting results, and the implication of PPARα therein...
متن کاملThe total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice
Objective(s): This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action.Materials and Methods: The db/db mice were divided into 5 groups: the normal group (NC), the diabetic group (DM), t...
متن کاملThe effect of Nitrochalcone on biochemical indicators and PPAR-α gene expression in nonalcoholic male NMRI mice steatosis model
Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with oxidative stress, inflammation, and decrease in peroxisome proliferator-activated receptor alpha (PPAR-α) expression. Nitrochalcone is effective ingredient of chalcones with anti-inflammatory, anti-cancer and anti-hyperglycemic properties. This study examined the effect of intraperitoneal (IP) administration of nitrochal...
متن کاملApolipoprotein E Polymorphism in an Iranian Hypercholestrolemic Population
Apolipoprotein E (apo E) is a structural constituent of several serum lipoprotein classes. It plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (LDL) and chylomicron remnant receptors. Three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (E2, E3 and E4). The polymorphism is clinically significant, and it...
متن کامل